Cumulative Incidence and Predictors of Progression in Corticosteroid-Naïve Patients with Sarcoidosis

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Cumulative Incidence and Predictors of Progression in Corticosteroid-Naïve Patients with Sarcoidosis

BACKGROUND Assessment of the clinical course of sarcoidosis requires long-term observation. However, the appropriate period of follow-up for sarcoidosis remains unclear, especially in patients without indication of corticosteroid therapy at the time of diagnosis. OBJECTIVE This study aimed to clarify the cumulative incidence and identify risk factors for disease progression in corticosteroid-...

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Corticosteroid treatment in sarcoidosis.

At present there is no curative treatment for sarcoidosis. Immunosuppressive and/or immunomodulatory drugs can, however, be used for controlling the disease. Corticosteroids remain the mainstay of therapy. They function by suppressing the pro-inflammatory cytokines and chemokines that are involved in cell-mediated immune responses and granuloma formation. Only in a select group of patients is i...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2015

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0143371